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The researchers noted that glucagon and GLP-1 can produce positive chronotropic and positive inotropic effects on the heart, but analyzed that the magnitude of the increase was similar to levels reported for existing GLP-1 receptor agonists

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One compelling histopathological correlate of disability progression is the slowly-expanding lesion, characterized by a presumably inactive gliotic demyelinated center surrounded by a rim of activated microglia and macrophages containing degenerated myelin, injured axons and often iron deposition (Dal-Bianco et al., 2017

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